In vitro activation of the pyruvate dehydrogenase complex in human muscle by a broad specificity protein phosphatase.

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作者信息

Toshima K, Kuroda Y, Takeda E, Watanabe T, Ito M, Naito E, Miyao M, Nonaka I, Tamagawa K, Toyofuku T

出版信息

J Inherit Metab Dis. 1984;7(3):143-4. doi: 10.1007/BF01801778.

DOI:10.1007/BF01801778

PMID:6094912

Abstract

摘要

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In vitro activation of the pyruvate dehydrogenase complex in human muscle by a broad specificity protein phosphatase.

J Inherit Metab Dis. 1984;7(3):143-4. doi: 10.1007/BF01801778.

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Pigeon liver phosphoprotein phosphatase: an effective activator of pyruvate dehydrogenase in tissue homogenates.鸽肝磷酸蛋白磷酸酶：组织匀浆中丙酮酸脱氢酶的有效激活剂。

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Pyruvate-dehydrogenase complex in ataxic patients: enzyme deficiency in ataxic encephalopathy plus lactic acidosis and normal activity in Friedreich ataxia.

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Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.在分离的质膜 - 线粒体混合物中，胰岛素对丙酮酸脱氢酶的刺激作用是通过激活丙酮酸脱氢酶磷酸酶来实现的。

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Insulin mediator causes dephosphorylation of the alpha subunit of pyruvate dehydrogenase by stimulating phosphatase activity.胰岛素介质通过刺激磷酸酶活性导致丙酮酸脱氢酶α亚基去磷酸化。

Arch Biochem Biophys. 1985 Feb 15;237(1):142-50. doi: 10.1016/0003-9861(85)90263-2.

Human muscle pyruvate dehydrogenase activity.

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Muscle pathology in cytochrome c oxidase deficiency.细胞色素c氧化酶缺乏症中的肌肉病理学

Acta Neuropathol. 1988;77(2):152-60. doi: 10.1007/BF00687425.

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Enzymologic studies and therapy of Leigh's disease associated with pyruvate decarboxylase deficiency.与丙酮酸脱羧酶缺乏相关的 Leigh 病的酶学研究及治疗

Pediatr Res. 1982 Jun;16(6):430-5. doi: 10.1203/00006450-198206000-00006.

Activation of the branched-chain alpha-ketoacid dehydrogenase complex by a broad specificity protein phosphatase.一种具有广泛特异性的蛋白磷酸酶对支链α-酮酸脱氢酶复合体的激活作用。

Biochem Biophys Res Commun. 1982 Aug 31;107(4):1497-503. doi: 10.1016/s0006-291x(82)80168-x.

Pyruvate dehydrogenase complex activity in normal and deficient fibroblasts.正常和成纤维细胞缺陷型中的丙酮酸脱氢酶复合物活性

J Clin Invest. 1981 May;67(5):1463-71. doi: 10.1172/jci110176.

Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion.大鼠心脏和肾脏中丙酮酸脱氢酶的活性和非活性形式：糖尿病、禁食和再喂养对丙酮酸脱氢酶相互转化的影响。

Arch Biochem Biophys. 1971 Apr;143(2):593-601. doi: 10.1016/0003-9861(71)90244-x.

Rapid diagnosis of pyruvate and ketoglutarate dehydrogenase deficiencies in platelet-enriched preparations from blood.

Clin Chim Acta. 1977 Feb 15;75(1):21-30. doi: 10.1016/0009-8981(77)90496-x.

Defective activation of the pyruvate dehydrogenase complex in subacute necrotizing encephalomyelopathy (Leigh disease).亚急性坏死性脑脊髓病（利氏病）中丙酮酸脱氢酶复合体的激活缺陷。

Ann Neurol. 1979 Dec;6(6):483-94. doi: 10.1002/ana.410060605.

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