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Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.

作者信息

Popp D A, Kiechle F L, Kotagal N, Jarett L

出版信息

J Biol Chem. 1980 Aug 25;255(16):7540-3.

PMID:6249805
Abstract
摘要

相似文献

1
Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.在分离的质膜 - 线粒体混合物中，胰岛素对丙酮酸脱氢酶的刺激作用是通过激活丙酮酸脱氢酶磷酸酶来实现的。
J Biol Chem. 1980 Aug 25;255(16):7540-3.
2
Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin.丙酮酸脱氢酶磷酸磷酸酶对镁离子的敏感性。精胺和胰岛素的类似作用。
Biochem J. 1986 Aug 15;238(1):83-91. doi: 10.1042/bj2380083.
3
Isolation from rat adipocytes of a chemical mediator for insulin activation of pyruvate dehydrogenase.从大鼠脂肪细胞中分离出一种用于胰岛素激活丙酮酸脱氢酶的化学介质。
Diabetes. 1980 Oct;29(10):852-5. doi: 10.2337/diacare.20.10.852.
4
Insulin mediator causes dephosphorylation of the alpha subunit of pyruvate dehydrogenase by stimulating phosphatase activity.胰岛素介质通过刺激磷酸酶活性导致丙酮酸脱氢酶α亚基去磷酸化。
Arch Biochem Biophys. 1985 Feb 15;237(1):142-50. doi: 10.1016/0003-9861(85)90263-2.
5
Persistence of the effect of insulin on pyruvate dehydrogenase activity in rat white and brown adipose tissue during the preparation and subsequent incubation of mitochondria.在制备大鼠白色和棕色脂肪组织线粒体及随后的孵育过程中，胰岛素对丙酮酸脱氢酶活性的影响持续存在。
Biochem J. 1984 Jan 15;217(2):441-52. doi: 10.1042/bj2170441.
6
Activation of pyruvate dehydrogenase in adipose tissue by insulin. Evidence for an effect of insulin on pyruvate dehydrogenase phosphate phosphatase.胰岛素对脂肪组织中丙酮酸脱氢酶的激活作用。胰岛素对丙酮酸脱氢酶磷酸磷酸酶作用的证据。
Biochem J. 1975 May;148(2):229-35. doi: 10.1042/bj1480229.
7
[Effect of thiamine phosphates on the activity of regulatory enzymes of the pyruvate dehydrogenase complex].[硫胺素磷酸酯对丙酮酸脱氢酶复合体调节酶活性的影响]
Ukr Biokhim Zh (1978). 1987 Sep-Oct;59(5):49-54.
8
Calcium ions and the regulation of pyruvate dehydrogenase.钙离子与丙酮酸脱氢酶的调节
Biochem Soc Symp. 1974(39):75-88.
9
Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle.胰岛素生成的肌肉介质激活脂肪细胞线粒体中的丙酮酸脱氢酶。
Science. 1979 Dec 21;206(4425):1407-8. doi: 10.1126/science.505013.
10
Mechanism of activation of pyruvate dehydrogenase by mitogens in pig lymphocytes.猪淋巴细胞中促细胞分裂剂激活丙酮酸脱氢酶的机制。
Biochem J. 1983 Nov 15;216(2):359-67. doi: 10.1042/bj2160359.

引用本文的文献

1
Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.线粒体活性氧对丙酮酸脱氢酶激酶 2 的失活作用。
J Biol Chem. 2012 Oct 12;287(42):35153-35160. doi: 10.1074/jbc.M112.400002. Epub 2012 Aug 21.
2
D-chiro-inositol glycans in insulin signaling and insulin resistance.D-手性肌醇聚糖在胰岛素信号和胰岛素抵抗中的作用。
Mol Med. 2010 Nov-Dec;16(11-12):543-52. doi: 10.2119/molmed.2010.00107. Epub 2010 Aug 27.
3
Insulin restores expression of adenosine kinase in streptozotocin-induced diabetes mellitus rats.
胰岛素可恢复链脲佐菌素诱导的糖尿病大鼠中腺苷激酶的表达。
Mol Cell Biochem. 2002 Jul;236(1-2):163-71. doi: 10.1023/a:1016163517896.
4
Derangements of pyruvate dehydrogenase in circulating lymphocytes of NIDDM patients and their healthy offspring.非胰岛素依赖型糖尿病患者及其健康后代循环淋巴细胞中丙酮酸脱氢酶的紊乱
J Endocrinol Invest. 1999 Jul-Aug;22(7):519-26. doi: 10.1007/BF03343603.
5
Molecular effects of sulphonylurea agents in circulating lymphocytes of patients with non-insulin-dependent diabetes mellitus.磺酰脲类药物对非胰岛素依赖型糖尿病患者循环淋巴细胞的分子效应。
Br J Clin Pharmacol. 1998 Mar;45(3):291-9. doi: 10.1046/j.1365-2125.1998.00680.x.
6
Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities.胰岛素作用的潜在介质：丙酮酸脱氢酶和腺苷酸环化酶活性的调节
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3513-7. doi: 10.1073/pnas.79.11.3513.
7
Prolactin induces release of a factor from membranes capable of stimulating beta-casein gene transcription in isolated mammary cell nuclei.催乳素可诱导细胞膜释放一种因子，该因子能够刺激分离出的乳腺细胞核中β-酪蛋白基因的转录。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6729-33. doi: 10.1073/pnas.78.11.6729.
8
Regulation of pyruvate dehydrogenase kinase activity by protein thiol-disulfide exchange.通过蛋白质硫醇-二硫键交换对丙酮酸脱氢酶激酶活性的调节。
Proc Natl Acad Sci U S A. 1982 Jul;79(13):3945-8. doi: 10.1073/pnas.79.13.3945.
9
Phospholipids and the regulation of pyruvate dehydrogenase from rat adipocyte mitochondria.磷脂与大鼠脂肪细胞线粒体丙酮酸脱氢酶的调节
Mol Cell Biochem. 1983;56(2):99-105. doi: 10.1007/BF00227209.
10
A partial view of the mechanism of insulin action.胰岛素作用机制的部分观点。
Diabetologia. 1981 Oct;21(4):347-62. doi: 10.1007/BF00252681.