与维生素D抵抗性佝偻病相关的肾小管性酸中毒。磷酸盐缺乏的作用。
Renal tubular acidosis associated with vitamin D-resistant rickets. Role of phosphate depletion.
作者信息
Minari M, Castellani A, Garella S
出版信息
Miner Electrolyte Metab. 1984;10(6):371-4.
PMID:6095003
Abstract
3 children with vitamin D-resistant rickets (VDRR), and severe phosphate depletion had moderate metabolitic acidosis and evidence of impaired distal tubular acidifying mechanisms. Therapy with 1-alpha-OH-vitamin D3 and phosphate supplementation improved the clinical and radiological rachitic manifestations, and resulted in the normalization of systemic acid-base parameters as well as of tubular acidification. Profound phosphate depletion is another cause of acquired, reversible distal renal tubular acidosis (RTA).
摘要
3名患有维生素D抵抗性佝偻病（VDRR）且严重磷酸盐缺乏的儿童出现中度代谢性酸中毒，并有远端肾小管酸化机制受损的证据。使用1-α-羟维生素D3和补充磷酸盐进行治疗改善了临床和放射学上的佝偻病表现，并使全身酸碱参数以及肾小管酸化恢复正常。严重的磷酸盐缺乏是获得性、可逆性远端肾小管酸中毒（RTA）的另一个原因。
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