van den Elsen P, Shepley B A, Borst J, Coligan J E, Markham A F, Orkin S, Terhorst C
Nature. 1984;312(5993):413-8. doi: 10.1038/312413a0.
The complete amino acid sequence of one of the polypeptide chains of the human T3/T-cell receptor complex, the T3 glycoprotein (T3-delta-chain) of relative molecular mass 20,000, was deduced from cDNA clones derived from HPB-ALL cells and a human T-cell clone. Inspection of the 171-amino acid sequence reveals a signal peptide, a 79-amino acid extracellular domain, one transmembrane region and a 44-amino acid intracellular domain which show no sequence homology with members of the T-cell receptor/immunoglobulin/MHC multi-gene family. The T3 delta-chain is coded for by a single-copy gene the expression of which is restricted to T lymphocytes in humans and mice.
人类T3/T细胞受体复合物的一条多肽链——相对分子质量为20,000的T3糖蛋白(T3δ链)的完整氨基酸序列,是从源自HPB-ALL细胞和一个人类T细胞克隆的cDNA克隆推导出来的。对171个氨基酸序列的检查揭示出一个信号肽、一个79个氨基酸的细胞外结构域、一个跨膜区域和一个44个氨基酸的细胞内结构域,这些结构域与T细胞受体/免疫球蛋白/MHC多基因家族的成员没有序列同源性。T3δ链由一个单拷贝基因编码,其表达在人类和小鼠中仅限于T淋巴细胞。