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在正确的时间拥有正确的团队：TCR 诱导的酪氨酸激酶激活。

The right team at the right time to go for a home run: tyrosine kinase activation by the TCR.

机构信息

Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Departments of Medicine and of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA.

出版信息

Nat Immunol. 2010 Feb;11(2):101-4. doi: 10.1038/ni0210-101.

DOI:10.1038/ni0210-101
PMID:20084063
Abstract

The TCR signals via cytoplasmic tyrosine kinases. Art Weiss recounts discoveries that led to early understanding of these events.

摘要

TCR 通过细胞质酪氨酸激酶发出信号。Art Weiss 讲述了这些发现如何引领人们早期对这些事件的理解。

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1
The right team at the right time to go for a home run: tyrosine kinase activation by the TCR.在正确的时间拥有正确的团队：TCR 诱导的酪氨酸激酶激活。
Nat Immunol. 2010 Feb;11(2):101-4. doi: 10.1038/ni0210-101.
2
Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase.Syk酪氨酸蛋白激酶对T细胞抗原受体信号传导的调节
Mol Cell Biol. 1997 Aug;17(8):4434-41. doi: 10.1128/MCB.17.8.4434.
3
IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-I.白细胞介素-2诱导型T细胞激酶（ITK）找到了另一个（舞蹈）伙伴……TFII-I。
Eur J Immunol. 2009 Sep;39(9):2354-7. doi: 10.1002/eji.200939813.
4
The activation of Csk by CD4 interferes with TCR-mediated activatory signaling.CD4对Csk的激活会干扰TCR介导的激活信号。
Eur J Immunol. 2003 Sep;33(9):2609-18. doi: 10.1002/eji.200324064.
5
Interactions of TCR tyrosine based activation motifs with tyrosine kinases.基于酪氨酸的TCR激活基序与酪氨酸激酶的相互作用。
Semin Immunol. 1995 Feb;7(1):13-20. doi: 10.1016/1044-5323(95)90003-9.
6
Signaling pathways that regulate T cell development and differentiation.调节T细胞发育和分化的信号通路。
J Immunol. 2012 Dec 15;189(12):5487-8. doi: 10.4049/jimmunol.1290076.
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The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.EMT/ITK/TSK（EMT）酪氨酸激酶在TCR信号传导过程中被激活：LCK是EMT最佳激活所必需的。
J Immunol. 1996 Apr 15;156(8):2716-22.
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Initiation of signal transduction by receptor aggregation: role of nonreceptor tyrosine kinases.受体聚集引发信号转导：非受体酪氨酸激酶的作用
Semin Immunol. 1995 Feb;7(1):3-11. doi: 10.1016/1044-5323(95)90002-0.
9
TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway.TCR和CD28通过ZAP-70与Vav/Rac-1-/PAK-1/p38丝裂原活化蛋白激酶信号通路的激活相偶联。
J Immunol. 1999 Jul 15;163(2):844-53.
10
Pillars article: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 1994. 263: 1136-1139.支柱文章：TCR与两种不同细胞质酪氨酸激酶的顺序相互作用。《科学》。1994年。第263卷：第1136 - 1139页。
J Immunol. 2014 Nov 1;193(9):4279-82.

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Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.抑制ZAP-70酪氨酸激酶活性的结构基础。
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T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases.T细胞抗原受体信号转导：尾巴与细胞质蛋白酪氨酸激酶的故事
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ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.ZAP-70缺乏症以常染色体隐性形式表现为严重联合免疫缺陷。
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Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.由于T细胞酪氨酸激酶ZAP-70缺陷导致的人类重症联合免疫缺陷。
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The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.T细胞上主要组织相容性复合体限制的抗原受体。I. 用单克隆抗体进行分离。
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