Reth M G, Alt F W
Nature. 1984;312(5993):418-23. doi: 10.1038/312418a0.
It has been found that most immunoglobulin heavy(H)-chain gene diversity (D) segments carry their own 5' transcriptional promoter element. Transcription of rearrangements which use heavy-chain D and joining (J) segments in B-lymphoid cells ultimately leads to the production of a Dmu messenger RNA which contains the DJH segments linked to the mu heavy-chain constant region. If the D is joined to the JH segment in the appropriate translational reading frame, this Dmu mRNA is translated to yield a short Dmu protein with a variable DJH N-terminus.
已发现大多数免疫球蛋白重链（H）基因多样性（D）区段都带有自身的5'转录启动子元件。在B淋巴细胞中利用重链D和连接（J）区段的重排转录最终导致产生一种Dμ信使RNA，其包含与μ重链恒定区相连的DJH区段。如果D以适当的翻译阅读框与JH区段连接，这种Dμ mRNA会被翻译产生一种具有可变DJH N末端的短Dμ蛋白。
