Bergouignan F X, Saintarailles J, Roux D, Guillon J, Bonnici J F, Fleury H, Henry P
Presse Med. 1984 Oct 20;13(37):2241-3.
The attenuated poliovirus vaccine is remarkably effective in preventing the disease but its innocuity has always been questioned. It seems to be responsible for occasional cases of spinal paralysis occurring in developed countries where poliomyelitis has virtually been eradicated. The authors report two cases of acute anterior poliomyelitis in young adults, in which the poliovirus recovered from the faeces might have been of vaccinal origin. Virological techniques do not always characterize the strains isolated, nor distinguish between a vaccinal mutant and a wild poliovirus. These data, together with previously published cases, have prompted the authors to discuss whether the use of a live poliovaccine is justified.
减毒脊髓灰质炎病毒疫苗在预防该疾病方面非常有效，但它的安全性一直受到质疑。在脊髓灰质炎实际上已被根除的发达国家，它似乎是偶尔发生的脊髓麻痹病例的病因。作者报告了两例年轻成人急性脊髓灰质炎病例，从粪便中分离出的脊髓灰质炎病毒可能来源于疫苗。病毒学技术并不总能鉴定所分离的毒株，也无法区分疫苗突变株和野生脊髓灰质炎病毒。这些数据以及先前发表的病例促使作者讨论使用活脊髓灰质炎疫苗是否合理。
