Lack of effects of thallium on GABAergic mechanisms in discrete areas of the rat brain.

The effects of intramuscular treatment for 3 and 5 consecutive days with thallium sulphate (2.5, 5 and 10 mg/Kg) on GABA content, glutamate - decarboxylase (GAD) and GABA-transaminase (GABA-T) activity in different areas of the rat brain were studied. Thallium at the dose levels used did not produce significant changes in GABA content, GAD and GABA-T activity in the brain hemispheres, brainstem, hypothalamus, diencephalon and caudate nucleus.