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铊对大鼠脑离散区域中γ-氨基丁酸能机制无影响。

Lack of effects of thallium on GABAergic mechanisms in discrete areas of the rat brain.

作者信息

Nisticò G, Faraone V, Naccari F, Ammendola D, Germanò D, Marmo E

出版信息

Res Commun Chem Pathol Pharmacol. 1984 Oct;46(1):35-42.

PMID:6095386
Abstract

The effects of intramuscular treatment for 3 and 5 consecutive days with thallium sulphate (2.5, 5 and 10 mg/Kg) on GABA content, glutamate - decarboxylase (GAD) and GABA-transaminase (GABA-T) activity in different areas of the rat brain were studied. Thallium at the dose levels used did not produce significant changes in GABA content, GAD and GABA-T activity in the brain hemispheres, brainstem, hypothalamus, diencephalon and caudate nucleus.

摘要

研究了连续3天和5天肌肉注射硫酸铊(2.5、5和10毫克/千克)对大鼠脑不同区域γ-氨基丁酸(GABA)含量、谷氨酸脱羧酶(GAD)和GABA转氨酶(GABA-T)活性的影响。所用剂量水平的铊未使大脑半球、脑干、下丘脑、间脑和尾状核中的GABA含量、GAD和GABA-T活性产生显著变化。

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