Uei Y, Kanzaki M
Acta Pathol Jpn. 1984 Sep;34(5):971-8. doi: 10.1111/j.1440-1827.1984.tb07628.x.
Twenty-seven postmortem pituitary glands were electron microscopically investigated. Eighteen of them revealed an accumulation of fine microfilaments in the cytoplasm ranging from 70 to 80 A in width, which is equivalent to a hyaline change in Crooke's cells seen with a light microscope. Since Crooke's changes were immunohistochemically evidenced to occur exclusively in ACTH cells, we examined their secretory granules quantitatively and concluded that the majority of them were ovoid, homogeneously electron dense and measured 200 to 450 nm in diameter averaging 332 nm. Occasionally, those irregularly shaped and larger than 600 nm were observed.
对27个垂体进行了电子显微镜检查。其中18个显示细胞质中存在宽度为70至80埃的细微丝聚集，这相当于光镜下所见克鲁克细胞的透明样变。由于免疫组化证实克鲁克样变仅发生在促肾上腺皮质激素（ACTH）细胞中，我们对其分泌颗粒进行了定量检查，得出的结论是，大多数分泌颗粒呈椭圆形，电子密度均匀，直径为200至450纳米，平均为332纳米。偶尔也会观察到形状不规则且大于600纳米的颗粒。
