McGahan J P, Dublin A B, Sassenrath E
Am J Dis Child. 1984 Dec;138(12):1109-12. doi: 10.1001/archpedi.1984.02140500015005.
High-resolution computed tomographic (CT) scanning of the brain was performed on three groups of rhesus monkeys for the detection of ventricular or cisternal enlargement. These three groups comprised four age-matched controls that had no prior drug usage--four monkeys receiving short-term (two to ten months) orally administered delta-9-tetrahydrocannabinol (delta 9-THC [now known nonproprietarily as dronabinol] and four monkeys receiving long-term (five years) orally administered delta 9-THC. Our results show a statistically significant enlargement of the frontal horns and the bicaudate distance in the long-term group as compared with the control and less significant enlargement of these areas in the long-term group compared with the short-term group. These findings suggest atrophy of the head of the caudate nucleus and the frontal portion of the brain of rhesus monkeys receiving long-term treatment with delta 9-THC.
对三组恒河猴进行脑部高分辨率计算机断层扫描（CT），以检测脑室或脑池扩大情况。这三组包括四只年龄匹配且无先前用药史的对照组猴子——四只接受短期（两至十个月）口服Δ⁹-四氢大麻酚（Δ⁹-THC，现通用名称为屈大麻酚）的猴子，以及四只接受长期（五年）口服Δ⁹-THC的猴子。我们的结果显示，与对照组相比，长期组的额角和双侧尾状核间距有统计学意义的扩大，且与短期组相比，长期组这些区域的扩大不太显著。这些发现表明，接受长期Δ⁹-THC治疗的恒河猴尾状核头部和脑部额叶部分出现萎缩。
