Aigner T G
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892.
Psychopharmacology (Berl). 1988;95(4):507-11. doi: 10.1007/BF00172964.
The effects of orally administered delta-9-tetrahydrocannabinol (THC) were evaluated on two different learning abilities in monkeys. Visual recognition memory, known to depend on limbic system integrity, was tested by means of delayed nonmatching-to-sample and found to be significantly impaired by acute administration of 2 and 4 mg/kg THC given 1 or 2 h prior to testing. Performance was significantly impaired throughout a 21-day period of repeated administration of 4 mg/kg THC and also during a 3-5 day period that began 7-10 days after the last dose of THC. By contrast, 24-h concurrent discrimination learning, a task that monkeys with limbic lesions can perform normally, was not impaired by THC, even following doses as high as 16 mg/kg. These results suggest that THC interferes with recognition memory more than discrimination learning, possibly reflecting a selective action of THC on limbic mechanisms.
评估了口服Δ⁹-四氢大麻酚（THC）对猴子两种不同学习能力的影响。视觉识别记忆已知依赖于边缘系统的完整性，通过延迟非匹配样本测试进行检测，结果发现，在测试前1或2小时急性给予2和4mg/kg THC会使其显著受损。在21天重复给予4mg/kg THC的期间以及在最后一剂THC后7 - 10天开始的3 - 5天期间，表现均显著受损。相比之下，24小时同时进行的辨别学习（一项边缘系统损伤的猴子仍能正常执行的任务）即使在给予高达16mg/kg的剂量后也未受到THC的损害。这些结果表明，THC对识别记忆的干扰大于对辨别学习的干扰，这可能反映了THC对边缘系统机制的选择性作用。
