Penfield A, Dale M M
Biochem Biophys Res Commun. 1984 Nov 30;125(1):332-6. doi: 10.1016/s0006-291x(84)80372-1.
Concentrations of the calcium ionophore A23187 and 1-oleoyl-2-acetyl-glycerol, which on their own are minimally effective in stimulating superoxide release from human neutrophils, show marked mutual potentiation when given simultaneously. The potentiating effect of the diacylglycerol can be shown to be dose-related. These results support the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in signal transduction for the respiratory burst in the human neutrophil.
钙离子载体A23187和1-油酰基-2-乙酰基甘油单独使用时，刺激人中性粒细胞释放超氧化物的效果甚微，但同时给予时则显示出明显的相互增强作用。二酰基甘油的增强作用呈剂量依赖性。这些结果支持了以下假说，即胞质钙和蛋白激酶C之间的协同作用参与了人中性粒细胞呼吸爆发的信号转导。
