佛波酯与A23187在中性粒细胞产生超氧化物过程中的协同作用。
Synergism between phorbol ester and A23187 in superoxide production by neutrophils.
作者信息
Dale M M, Penfield A
出版信息
FEBS Lett. 1984 Sep 17;175(1):170-2. doi: 10.1016/0014-5793(84)80592-x.
PMID:6090208
Abstract
Concentrations of phorbol myristate acetate and the calcium ionophore, A23187, which by themselves are minimally effective in stimulating superoxide generation in human neutrophils show marked mutual potentiation when given together. This supports the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in the stimulus/activation coupling of the respiratory burst in the neutrophil.
摘要
佛波醇肉豆蔻酸酯乙酸盐和钙离子载体A23187本身在刺激人中性粒细胞产生超氧化物方面效果甚微，但当两者一起使用时，却显示出显著的相互增强作用。这支持了一种假说，即胞质钙和蛋白激酶C之间的协同作用参与了中性粒细胞呼吸爆发的刺激/激活偶联过程。
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