Mel'nik E I, Timoshin S S, Lupandin A V
Biull Eksp Biol Med. 1984 Dec;98(12):718-20.
A study was made of the possibility of correcting with shizandra lignans of the cell manifestations of disadaptation in animals exposed to chronic cold stress. The stress was simulated by a 1.5-hour cooling of the animals to 28-30 degrees C for 28 days. The cell disadaptation test was used for determination of the level of pathological mitoses (PM). The processes of cell division were evaluated with the aid of the mitotic index and radioautography of DNA synthesis. Administration of shizandra to the stress-exposed animals for 28 days averted the stress-induced elevation of the PM level in the corneal epithelium. The use of shizandra lignans also promoted the normalization of DNA synthesis and mitotic activity in the tissues under examination.
研究了用五味子木脂纠正长期冷应激动物适应不良细胞表现的可能性。通过将动物冷却至28 - 30摄氏度并持续1.5小时，共28天来模拟应激。细胞适应不良试验用于测定病理性有丝分裂（PM）水平。借助有丝分裂指数和DNA合成放射自显影评估细胞分裂过程。给遭受应激的动物服用五味子28天，可避免应激引起的角膜上皮PM水平升高。使用五味子木脂还促进了所检查组织中DNA合成和有丝分裂活性的正常化。
