Merkle R K, Cooper K K, Rutherford C L
Cell Differ. 1984 Oct;14(4):257-66. doi: 10.1016/0045-6039(84)90014-9.
Cyclic AMP functions as the chemotactic signal during aggregation of amoebae of the cellular slime mold Dictyostelium discoideum. Evidence suggests that cAMP also acts as a regulatory molecule during Dictyostelium multicellular differentiation. We have used ultramicrotechniques and a sensitive radioimmunoassay to measure the levels of cAMP within the culmination stage individual. We show that there is a peak of cAMP at the culmination stage of development and that in the individual at this stage the molecule is localized in a gradient within the spore mass.
环磷酸腺苷（cAMP）在细胞黏菌盘基网柄菌的变形虫聚集过程中作为趋化信号发挥作用。有证据表明，cAMP在盘基网柄菌多细胞分化过程中也作为一种调节分子发挥作用。我们使用了超微技术和灵敏的放射免疫分析法来测量发育成熟阶段个体内的cAMP水平。我们发现，在发育成熟阶段存在一个cAMP峰值，并且在这个阶段的个体中，该分子以梯度形式定位在孢子团内。
