环磷酸腺苷诱导盘基网柄菌蛞蝓体中柄细胞和孢子细胞的分化

Induction of stalk and spore cell differentiation by cyclic AMP in slugs of Dictyostelium discoideum.

作者信息

Feit I N, Fournier G A, Needleman R D, Underwood M Z

出版信息

Science. 1978 Apr 28;200(4340):439-41. doi: 10.1126/science.205945.

DOI:10.1126/science.205945

PMID:205945

Abstract

Multicellular masses of the cellular slime mold Dictyostelium discoideum, under conditions which ordinarily suppress cell differentiation, develop clusters of stalk cells and spore cells when implanted with Sephadex particles that had been soaked in 5 X 10(-3)M cyclic adenosine monophosphate (AMP). A possible relation exists between oxygen gradients, cyclic AMP gradients, and the pattern of morphogenesis and cell differentiation during fruiting.

摘要

在通常会抑制细胞分化的条件下，将浸泡在5×10⁻³M环磷酸腺苷（AMP）中的葡聚糖凝胶颗粒植入多细胞团块的细胞性黏菌盘基网柄菌时，会形成柄细胞和孢子细胞簇。在子实体形成过程中，氧梯度、环磷酸腺苷梯度与形态发生和细胞分化模式之间可能存在关联。