杜兴氏肌营养不良症患者肌肉和血小板中的钙激活中性蛋白酶。

Calcium-activated neutral protease from muscle and platelets of Duchenne muscular dystrophy cases.

作者信息

Rabbani N, Moses L, Anandavalli T E, Anandaraj M P

出版信息

Clin Chim Acta. 1984 Nov 15;143(2):163-8. doi: 10.1016/0009-8981(84)90224-9.

Abstract

Calcium-activated neutral protease (CANP) has been purified from its endogenous inhibitor and its activity is monitored in the muscle of Duchenne Muscular Dystrophy (DMD) patients. The specific activity of the enzyme is found to be significantly higher as compared to normal. CANP from platelets of DMD patients is significantly higher as compared to activities in other myopathies and controls. Platelet CANP, therefore, may prove to be an index of pathological condition in DMD, since other myopathies do not show such a significant change.

摘要

钙激活中性蛋白酶（CANP）已从其内源性抑制剂中纯化出来，并在杜氏肌营养不良症（DMD）患者的肌肉中监测其活性。发现该酶的比活性与正常情况相比显著更高。与其他肌病和对照组的活性相比，DMD患者血小板中的CANP显著更高。因此，血小板CANP可能被证明是DMD病理状况的一个指标，因为其他肌病并未显示出如此显著的变化。