Takasu N, Naka M, Mori T, Yamada T
Clin Endocrinol (Oxf). 1984 Oct;21(4):345-55. doi: 10.1111/j.1365-2265.1984.tb03221.x.
We examined the effects of IgG from four patients with autoimmune atrophic thyroiditis on cAMP responses and iodine metabolism (post-receptor processes), using cultured thyroid cells. We found two types of thyroid function-blocking antibodies: (1) one blocks TSH binding to its receptors and inhibits TSH-stimulated cAMP responses but does not block cAMP-stimulated iodine uptake and organification; (2) the other blocks TSH binding to its receptors, inhibits TSH-stimulated cAMP responses and does block cAMP-stimulated iodine uptake and organification (post-receptor processes). Among the four patients with autoimmune atrophic thyroiditis, three had TSH binding blocking antibodies only and one had antibodies which block post-receptor processes. These antibodies might be responsible for thyroid dysfunction in autoimmune atrophic thyroiditis. The daughter of one of the women with autoimmune atrophic thyroiditis had transient neonatal hypothyroidism and recovered spontaneously from the hypothyroid state with the disappearance of the maternal blocking antibodies.
我们使用培养的甲状腺细胞，研究了来自四名自身免疫性萎缩性甲状腺炎患者的IgG对环磷酸腺苷（cAMP）反应和碘代谢（受体后过程）的影响。我们发现了两种类型的甲状腺功能阻断抗体：（1）一种阻断促甲状腺激素（TSH）与其受体的结合，抑制TSH刺激的cAMP反应，但不阻断cAMP刺激的碘摄取和有机化；（2）另一种阻断TSH与其受体的结合，抑制TSH刺激的cAMP反应，并且确实阻断cAMP刺激的碘摄取和有机化（受体后过程）。在这四名自身免疫性萎缩性甲状腺炎患者中，三名仅有TSH结合阻断抗体，一名具有阻断受体后过程的抗体。这些抗体可能是自身免疫性萎缩性甲状腺炎中甲状腺功能障碍的原因。其中一名患有自身免疫性萎缩性甲状腺炎的女性的女儿患有短暂性新生儿甲状腺功能减退症，随着母体阻断抗体的消失，甲状腺功能减退状态自发恢复。
