Fike J R, Cann C E, Norman D, Turrel J M, LeCouteur R A, Pflugfeld C M, Borcich J K
Invest Radiol. 1984 Nov-Dec;19(6 Suppl):S312-6. doi: 10.1097/00004424-198411001-00007.
The magnitude and time course of contrast enhancement in spontaneous canine brain tumors was determined for two contrast agents: meglumine iothalamate and sodium meglumine ioxaglate. Tumor enhancement during contrast infusion and at 5, 10, 15, 30 and 45 minutes was measured using quantitative computed tomography. Blood iodine was measured using x-ray fluorescence. Peak contrast enhancement occurred during the infusion, and the magnitude was the same for both agents. Per gram of iodine infused, blood iodine was 12.4% higher with ioxaglate than iothalamate. The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors.
使用两种造影剂（碘他拉葡胺和碘克沙醇葡甲胺）测定自发性犬脑肿瘤中对比增强的幅度和时间进程。在对比剂注入期间以及注入后5、10、15、30和45分钟时，使用定量计算机断层扫描测量肿瘤增强情况。使用X射线荧光法测量血碘。对比增强峰值出现在注入期间，两种造影剂的增强幅度相同。每注入1克碘，碘克沙醇组的血碘比碘他拉葡胺组高12.4%。单离子二聚体碘克沙醇在增强犬脑肿瘤方面与碘他拉葡胺同样有效。
