Norman A, Ingram M, Skillen R G, Freshwater D B, Iwamoto K S, Solberg T
Department of Radiation Oncology, UCLA School of Medicine 90095-1721 USA.
Radiat Oncol Investig. 1997;5(1):8-14. doi: 10.1002/(SICI)1520-6823(1997)5:1<8::AID-ROI2>3.0.CO;2-1.
Brain masses diagnosed in 47 pet dogs as tumors by CT scans, and confirmed in 12 dogs by necropsies, were injected with iodinated contrast media and treated by a modified CT scanner, the CTRx. Twenty-six dogs that received six or more weekly treatments of about 5.6 Gy per fraction, of which about 25% was contributed by radiation from the iodine, for a median total dose of 39 Gy, had a median survival of 230 days. This compares well with the 150 days reported for 25 dogs given 46-48 Gy of cobalt-60 radiation to the whole brain, and is significantly greater than the 6 to 13 days in untreated historic controls.
47只宠物狗经CT扫描诊断为脑部肿块，其中12只经尸检确诊为肿瘤，向这些肿块注射碘化造影剂，并使用改良型CT扫描仪CTRx进行治疗。26只狗接受了每周6次或更多次的治疗，每次分割剂量约为5.6 Gy，其中约25%的剂量由碘辐射贡献，中位总剂量为39 Gy，这些狗的中位生存期为230天。这与25只接受全脑46 - 48 Gy钴-60辐射的狗报告的150天生存期相比良好，且显著长于未经治疗的历史对照中的6至13天。
