拉氧头孢（羟羧氧酰胺菌素）、头孢哌酮和头孢噻肟的血清杀菌活性。
The serum bactericidal activity of latamoxef (moxalactam), cefoperazone and cefotaxime.
作者信息
McNamee W, Drusano G L, Tatem B A, Standiford H C
出版信息
J Antimicrob Chemother. 1984 Nov;14(5):491-7. doi: 10.1093/jac/14.5.491.
We determined the serum bactericidal activity 1 h after the end of 2 g, 30 min infusions of latamoxef, cefoperazone and cefotaxime in six volunteers against six strains each of Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. All produced excellent serum bactericidal activity against E. coli. Latamoxef and cefotaxime were superior for K. pneumoniae. Cefoperazone produced the highest titres against Staph. aureus. None of these agents produced sufficient bactericidal activity against Ps. aeruginosa to be useful in initial single agent therapy for the septic, granulocytopenic cancer patient.
我们在6名志愿者静脉输注2g拉氧头孢、头孢哌酮和头孢噻肟30分钟结束后1小时，测定了其血清杀菌活性，针对大肠杆菌、肺炎克雷伯菌、金黄色葡萄球菌和铜绿假单胞菌的6个菌株。所有药物对大肠杆菌均产生了良好的血清杀菌活性。拉氧头孢和头孢噻肟对肺炎克雷伯菌效果更佳。头孢哌酮对金黄色葡萄球菌产生的效价最高。这些药物对铜绿假单胞菌均未产生足够的杀菌活性，因此对脓毒症、粒细胞减少的癌症患者进行初始单药治疗无效。
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