Asari S, Horikawa M, Tsukamoto H, Shimizu Y, Koda K, Hayashi C, Miyai K
Jpn J Antibiot. 1984 Feb;37(2):267-78.
Susceptibilities of 372 strains of bacteria to cefotaxime (CTX) were determined based on the inhibition zone diameter obtained by the single-disc method. Four categories were assessed. Susceptibility of clinical isolated to CTX and 3 other antibiotics. Against most strains, CTX showed higher antibacterial activity than other drugs in the low concentration, especially for S. aureus, S. pneumoniae, S. agalactiae, E. coli and P. morganii. Susceptibility of strains isolated from different clinical materials. CTX showed the highest antibacterial activity against most strains isolated from pus, blood and cerebrospinal fluid and showed higher activity against strains isolated from other materials, too. Susceptibility of clinical isolates in 7 different fields. CTX was shown to have uniformly higher antibacterial activity than other drugs against isolates from such fields as internal medicine, pediatrics, surgery, urology, obstetrics & gynecology, dermatology and otorhinolaryngology. CTX showed the highest antibacterial activity in dermatology. Susceptibility of all clinical isolates. CTX showed the highest antibacterial activity against isolated pathogenic 352 strains (except for P. aeruginosa of 20 strains).
基于单纸片法获得的抑菌圈直径，测定了372株细菌对头孢噻肟（CTX）的敏感性。评估了四类情况。临床分离株对CTX及其他3种抗生素的敏感性。在低浓度时，CTX对大多数菌株显示出比其他药物更高的抗菌活性，尤其是对金黄色葡萄球菌、肺炎链球菌、无乳链球菌、大肠杆菌和摩根氏菌。从不同临床材料分离的菌株的敏感性。CTX对从脓液、血液和脑脊液中分离的大多数菌株显示出最高的抗菌活性，对从其他材料中分离的菌株也显示出较高的活性。7个不同科室临床分离株的敏感性。CTX对来自内科、儿科、外科、泌尿外科、妇产科、皮肤科和耳鼻喉科等科室的分离株显示出始终高于其他药物的抗菌活性。CTX在皮肤科显示出最高的抗菌活性。所有临床分离株的敏感性。CTX对352株分离的致病菌株（除20株铜绿假单胞菌外）显示出最高的抗菌活性。
