人类肿瘤组织中的钴胺素和叶酸结合蛋白
Cobalamin and folate binding proteins in human tumour tissue.
作者信息
Sheppard K, Bradbury D A, Davies J M, Ryrie D R
出版信息
J Clin Pathol. 1984 Dec;37(12):1336-8. doi: 10.1136/jcp.37.12.1336.
Abstract
The serum of an 84 year old man with disseminated carcinoma was found to contain extremely high concentrations of cobalamin and of a cobalamin binding protein with trans-cobalamin I characteristics. Tumour tissue samples obtained at necropsy contained considerably higher concentrations of cobalamin binding protein (R-binder) than normal tissues. Tumour tissues also contained increased concentrations of specific folate binding protein. In all tissues studied a close correlation existed between unsaturated cobalamin and unsaturated folate binding and between total cobalamin and total folate binding. These results suggest related mechanisms for the synthesis of cobalamin binding proteins of the R-binder class and folate binding proteins by tumour tissue.
摘要
一名患有播散性癌的84岁男性的血清中发现含有极高浓度的钴胺素以及一种具有转钴胺素I特性的钴胺素结合蛋白。尸检时获取的肿瘤组织样本中钴胺素结合蛋白（R-结合蛋白）的浓度比正常组织高得多。肿瘤组织中特异性叶酸结合蛋白的浓度也有所增加。在所有研究的组织中，不饱和钴胺素与不饱和叶酸结合之间以及总钴胺素与总叶酸结合之间存在密切相关性。这些结果提示肿瘤组织合成R-结合蛋白类钴胺素结合蛋白和叶酸结合蛋白的机制相关。
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