Collier W L, Iacopino L, Amenta F
Mech Ageing Dev. 1984 Nov;28(1):41-5. doi: 10.1016/0047-6374(84)90151-9.
Using mature (12 months), old (70 months) rabbits and 3H-labeled spiroperidol, the characteristics of renal artery dopamine receptors were studied. In old age the dissociation constant of [3H]spiroperidol was unchanged, while maximum specific binding was reduced more than 45%. The present data seem to indicate an impairment of peripheral dopaminergic function in ageing.
利用成年（12个月）、老年（70个月）兔及3H标记的螺哌啶醇，对肾动脉多巴胺受体的特性进行了研究。老年时，[3H]螺哌啶醇的解离常数未变，而最大特异性结合减少超过45%。目前的数据似乎表明衰老过程中外周多巴胺能功能受损。
