Amenta F, Cavallotti C, De Rossi M, Sancesario G, Gerli R
Pharmacology. 1984;28(2):104-11. doi: 10.1159/000137950.
The distribution of 3H-spiroperidol binding sites within rabbit superior mesenteric artery was studied in normal as well as 6-hydroxydopamine (6-OHDA) sympathectomized animals using a histoautoradiographic technique. The labelled drug was located in the three layers of the artery (adventitia, media and intima), with the greater density in the media. In the adventitia the radiolabelled drug was located at the level of fibrous and connective cells. In the media 3H-spiroperidol was bound by smooth muscle cells and is found in the cellular membrane of the same cells. 6-OHDA administration causes an increase in the number of 3H-spiroperidol binding sites in the adventitia and as well as a 20-25% increase in the media. The possible existence of a direct dopaminergic innervation of the superior mesenteric artery is discussed.
运用组织放射自显影技术，在正常以及经6-羟基多巴胺（6-OHDA）交感神经切除的家兔肠系膜上动脉中，研究了3H-螺哌啶醇结合位点的分布情况。标记药物位于动脉的三层结构（外膜、中膜和内膜）中，其中中膜的密度更高。在外膜中，放射性标记药物位于纤维细胞和结缔组织细胞水平。在中膜中，3H-螺哌啶醇与平滑肌细胞结合，并存在于这些细胞的细胞膜中。给予6-OHDA会导致外膜中3H-螺哌啶醇结合位点数量增加，同时中膜中该结合位点数量增加20%-25%。文中讨论了肠系膜上动脉可能存在直接多巴胺能神经支配的情况。
