赤藓红在酵母中的遗传毒性。

Genetic toxicity of erythrosine in yeast.

作者信息

Matula T I, Downie R H

出版信息

Mutat Res. 1984 Nov-Dec;138(2-3):153-6. doi: 10.1016/0165-1218(84)90038-7.

Abstract

The genetic activity of erythrosine, a fluorescein dye used as a color additive, was studied in assays with growing cells of different strains of Saccharomyces cerevisiae. Erythrosine induced mitotic gene conversion and reverse mutation in strains D7 and XV185-14C of yeast. It failed, however, to increase mitotic recombination in strain D5. These results show that erythrosine possesses genotoxic activity for eukaryotic cells.

摘要

赤藓红是一种用作色素添加剂的荧光素染料，我们在对不同酿酒酵母菌株的生长细胞进行的试验中研究了其遗传活性。赤藓红在酵母的D7和XV185 - 14C菌株中诱导了有丝分裂基因转换和回复突变。然而，它未能增加D5菌株中的有丝分裂重组。这些结果表明，赤藓红对真核细胞具有遗传毒性活性。