Wei R, Ong T, Whong W, Frezza D, Bronzetti G, Zeiger E
Environ Mutagen. 1979;1(1):45-53. doi: 10.1002/em.2860010111.
The genetic activity of PR toxin, a mycotoxin from Penicillium roqueforti, was studied in Saccharomyces cerevisiae and Neurospora crassa. The results show that PR toxin, without enzymic activation, causes gene conversion in S. cerevisiae strains D4 and D7, reverse mutation in S. cerevisiae strain D7 and N. crassa strain N24, and mitotic crossing-over in S. cerevisiae strain D7, In the log phase cells of S. cerevisiae the effects are more pronounced at alkaline than at acid pH. The active site responsible for the genetic activity and toxicity is known. The carbonyl groups appear to play an important role in the biologic activity of this molecule.
对来自罗克福青霉的霉菌毒素PR毒素在酿酒酵母和粗糙脉孢菌中的遗传活性进行了研究。结果表明，未经酶激活的PR毒素会导致酿酒酵母菌株D4和D7发生基因转换，酿酒酵母菌株D7和粗糙脉孢菌菌株N24发生回复突变，以及酿酒酵母菌株D7发生有丝分裂交换。在酿酒酵母的对数期细胞中，碱性pH条件下的影响比酸性pH条件下更明显。已知负责遗传活性和毒性的活性位点。羰基似乎在该分子的生物活性中起重要作用。
