Cutler M G, Mackintosh J H
Neuropharmacology. 1984 Sep;23(9):1091-7. doi: 10.1016/0028-3908(84)90134-5.
Behavioural effects of cannabis and delta-9-tetrahydrocannabinol (THC) in male mice encountering solvent-treated males, and of cannabis in males encountering control females, were examined by ethological procedures. Effects on elements and element-groups within behavioural categories were investigated, and effects of cannabis on the response sequence to the behaviour of male partners examined. Effects were detected on elements that previously had been grouped within categories. Flight elements "flag, evade, retreat and flee" and immobility were increased both by cannabis (50 and 100 mg/kg in male-male encounters and 25 mg/kg in male-female encounters) and by THC (5 mg/kg), whereas "scan", "wash and self-groom" and some elements of social investigation were reduced. Bout length and duration of "explore" were increased by THC. In encounters with females, cannabis decreased sexual behaviour. Sequence analysis showed that cannabis, within the limitations of the comparatively small size of sample, to have no significant effect upon normal behavioural responses at 50 and 100 mg/kg, apart from enhancement of the flight response to aggression and some elements of social investigation by partners. These more detailed analyses revealed effects that would not be detectable by the conventional approach.
采用行为学方法研究了大麻和δ-9-四氢大麻酚（THC）对遇到经溶剂处理的雄性小鼠的雄性小鼠的行为影响，以及大麻对遇到对照雌性小鼠的雄性小鼠的行为影响。研究了对行为类别中的行为元素和元素组的影响，并考察了大麻对雄性伙伴行为反应序列的影响。检测到对先前归为一类的元素有影响。大麻（在雄-雄相遇中为50和100mg/kg，在雄-雌相遇中为25mg/kg）和THC（5mg/kg）均增加了逃避元素“挥舞、躲避、后退和逃跑”以及静止不动，而“扫视、清洗和自我梳理”以及社交探究的一些元素减少。THC增加了“探索”的回合长度和持续时间。在与雌性小鼠的相遇中，大麻减少了性行为。序列分析表明，在样本相对较小的限制范围内，50和100mg/kg的大麻对正常行为反应没有显著影响，除了增强对攻击的逃避反应以及伙伴社交探究的一些元素。这些更详细的分析揭示了传统方法无法检测到的影响。
