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大麻提取物对遭遇雄性狒狒(东非狒狒)社会行为的影响。

Influence of hashish extract on the social behaviour of encountering male baboons (Papio c. anubis).

作者信息

Sieber B

出版信息

Pharmacol Biochem Behav. 1982 Aug;17(2):209-16. doi: 10.1016/0091-3057(82)90071-5.

DOI:10.1016/0091-3057(82)90071-5
PMID:6291065
Abstract

The effects of hashish extract (2 mg delta 9-THC/kg)on the social behaviour of encountering male baboons were tested by ethological methods. In the "approaching" male the drug reduced "approach" and the aggressive elements "hit-ground", "brows-back" and "attack" but increased the frequency of "retreat". Social interactions were generally diminished. In the "retreating" male friendly social interactions as "lipsmack" and "touch-back/handle-genitals" were suppressed but the threatening elements "open-mouth" and "tooth-grind" were stimulated. "Retreat" was additionally more frequent. Non-social activities and locomotion were not affected in either of the males. Treating both subjects with hashish resulted in a reduction of "lipsmack", "approach", "fight" and "chase" in the approaching and "lipsmack", "touch-back/handle-genitals", "chase", "retreat" and "flee" in the retreating male. Social activities were generally reduced in both animals. Comparing the behavioural effects of hashish in male baboons to those described in other non-human primates, in rodents but also in man revealed analogous effects in all species. The drug generally impaired social interactions, induced social withdrawal and led to social isolation of the drugged subject.

摘要

采用行为学方法测试了大麻提取物(2毫克δ9-四氢大麻酚/千克)对遭遇雄性狒狒社会行为的影响。在“接近”的雄性狒狒中,该药物减少了“接近”行为以及攻击行为“撞击地面”“皱鼻”和“攻击”,但增加了“撤退”的频率。社交互动总体上减少。在“撤退”的雄性狒狒中,友好的社交互动如“咂嘴”和“触摸背部/触摸生殖器”受到抑制,但威胁性动作“张嘴”和“磨牙”受到刺激。“撤退”也更频繁。非社交活动和移动在两种雄性狒狒中均未受影响。对两只受试动物都使用大麻后,“接近”的雄性狒狒中“咂嘴”“接近”“打斗”和“追逐”减少,“撤退”的雄性狒狒中“咂嘴”“触摸背部/触摸生殖器”“追逐”“撤退”和“逃跑”减少。两只动物的社交活动总体上均减少。将大麻对雄性狒狒的行为影响与其他非人灵长类动物、啮齿动物以及人类中所描述的影响进行比较,发现所有物种中都有类似的影响。该药物通常会损害社交互动、导致社交退缩并使受试动物出现社会隔离。

相似文献

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Influence of hashish extract on the social behaviour of encountering male baboons (Papio c. anubis).大麻提取物对遭遇雄性狒狒(东非狒狒)社会行为的影响。
Pharmacol Biochem Behav. 1982 Aug;17(2):209-16. doi: 10.1016/0091-3057(82)90071-5.
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Behaviour in rats maintained by low differential reinforcement rate: effects of delta 1-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination.低差异强化率维持大鼠行为:δ-1-四氢大麻酚、大麻酚和大麻二酚单独及联合使用的效果
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Effects of delta 9-tetrahydrocannabinol, cannabinol and cannabidiol on the immune system in mice. II. In vitro investigation using cultured mouse splenocytes.δ9-四氢大麻酚、大麻酚和大麻二酚对小鼠免疫系统的影响。II. 使用培养的小鼠脾细胞进行的体外研究。
Pharmacology. 1983;26(1):12-9. doi: 10.1159/000137764.

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