Buckmaster E A, Gompels U, Minson A
Virology. 1984 Dec;139(2):408-13. doi: 10.1016/0042-6822(84)90387-8.
A type-specific monoclonal antibody that efficiently neutralises HSV-1 immunoprecipitated a glycoprotein of slightly greater electrophoretic mobility than gB from HSV-1 infected cells. Pulse and pulse chase experiments indicate that this glycoprotein is distinct from HSV-1 glycoproteins gB, gC, gD, and gE. This was confirmed by the reactions of LP11 with a series of intertypic recombinants the results of which indicate that the LP11 target gene is located close to the HSV-1 thymidine kinase gene between map positions 0.28 and 0.31. In accordance with the presently agreed convention this glycoprotein should be designated gH-1, and it may correspond to the 110K glycoprotein described by S. D. Showalter, M. Zweig, and B. Hampar (1981), Infect. Immun. 34, 684-692. Antibody LP11 inhibits plaque formation when added to cell monolayers after infection suggesting that gH-1 may play a role in cell-to-cell spread of infectious virus.
一种能有效中和单纯疱疹病毒1型（HSV-1）的型特异性单克隆抗体，从HSV-1感染细胞中免疫沉淀出一种电泳迁移率略高于gB的糖蛋白。脉冲和脉冲追踪实验表明，这种糖蛋白与HSV-1糖蛋白gB、gC、gD和gE不同。LP11与一系列型间重组体的反应证实了这一点，其结果表明LP11靶基因位于HSV-1胸苷激酶基因附近，图谱位置在0.28和0.31之间。根据目前公认的惯例，这种糖蛋白应命名为gH-1，它可能与S.D.Showalter、M.Zweig和B.Hampar（1981年，《感染与免疫》34卷，684 - 692页）描述的110K糖蛋白相对应。感染后向细胞单层中添加抗体LP11可抑制噬斑形成，这表明gH-1可能在感染性病毒的细胞间传播中起作用。
