Aoyagi T, Wada T, Ohuchi S, Kojima F, Nagai M, Kawahara F, Umezawa H
Biochem Int. 1984 Oct;9(4):405-11.
In order to understand the effects of an immunomodulator in vivo, we performed time series analysis on mice given an aminopeptidase inhibitor, bestatin. This agent, which is known to be an immunopotentiator, caused peculiar oscillation of the activities of various hydrolytic enzymes in spleen. Autocorrelation curves obtained from serial data of each enzymatic activity revealed that sine curve-type oscillations are brought about in enzyme networks by this inhibitor. Judging from the pattern of the variations of enzymatic activities, it seems that metabolic homeostasis is strongly affected by this agent. The inhibitor probably initiated the homeostatic movements directly and secondarily caused extensive changes in the enzyme networks in vivo. This effect of bestatin may be useful in altering the pathological homeostasis (such as the one in autoimmune diseases) by affecting the dynamic equilibrium among the various components in the immunological system.
为了解一种免疫调节剂在体内的作用，我们对给予氨肽酶抑制剂苯丁抑制素的小鼠进行了时间序列分析。这种已知为免疫增强剂的药物导致脾脏中各种水解酶活性出现奇特的振荡。从每种酶活性的系列数据获得的自相关曲线表明，该抑制剂在酶网络中引发了正弦曲线型振荡。从酶活性变化的模式判断，这种药物似乎强烈影响代谢稳态。该抑制剂可能直接启动了稳态运动，并继而在体内引起酶网络的广泛变化。苯丁抑制素的这种作用可能有助于通过影响免疫系统中各种成分之间的动态平衡来改变病理稳态（如自身免疫性疾病中的稳态）。
