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嘌呤与吗啡镇痛作用的关系。

Purine involvement in morphine antinociception.

作者信息

Mantegazza P, Tammiso R, Zambotti F, Zecca L, Zonta N

出版信息

Br J Pharmacol. 1984 Dec;83(4):883-8. doi: 10.1111/j.1476-5381.1984.tb16527.x.

DOI:10.1111/j.1476-5381.1984.tb16527.x
PMID:6097327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1986980/
Abstract

The effects of a series of adenosine derivatives on morphine antinoceptive effect were investigated in rats by the 'tail-flick' method. 2-Chloroadenosine (CADO) and L-N6-phenylisopropyladenosine (L-PIA), given intraperitoneally, caused decreased morphine antinociception. Intracerebroventricular injections of CADO, L-PIA and 5'-N-ethylcarboxamide adenosine (NECA), but not of 2'-deoxyadenosine, antagonized morphine antinociception. The effects of both central and peripheral injections of CADO and L-PIA on morphine antinociception were partially reversed by caffeine. Intracerebroventricular injection of dibutyryl-cyclic 3', 5' adenosine monophosphate (db cyclic AMP) had no effect on morphine antinociception. These data indicate that adenosine plays a role in morphine-induced antinociception. The results are discussed in terms of postulated effects of adenosine derivatives on adenylate cyclase.

摘要

采用“甩尾”法在大鼠中研究了一系列腺苷衍生物对吗啡镇痛作用的影响。腹腔注射2-氯腺苷（CADO）和L-N6-苯基异丙基腺苷（L-PIA）可导致吗啡镇痛作用减弱。脑室内注射CADO、L-PIA和5'-N-乙基羧酰胺腺苷（NECA），但不注射2'-脱氧腺苷，可拮抗吗啡镇痛作用。腹腔和脑室内注射CADO和L-PIA对吗啡镇痛作用的影响均被咖啡因部分逆转。脑室内注射二丁酰环3'，5'-单磷酸腺苷（db环磷酸腺苷）对吗啡镇痛作用无影响。这些数据表明腺苷在吗啡诱导的镇痛中起作用。根据腺苷衍生物对腺苷酸环化酶的假定作用对结果进行了讨论。

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本文引用的文献

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Antinociceptive effects in the rat of an adenosine analogue, N6-phenylisopropyladenosine.腺苷类似物N6-苯基异丙基腺苷对大鼠的镇痛作用。
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Adenosine receptors in the central nervous system: relationship to the central actions of methylxanthines.中枢神经系统中的腺苷受体：与甲基黄嘌呤类中枢作用的关系。
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