Karashima T, Okajima T, Kato K, Ibayashi H
Endocrinol Jpn. 1984 Oct;31(5):539-47. doi: 10.1507/endocrj1954.31.539.
The effects of cholecystokinin octapeptide (CCK) and bombesin on rat plasma growth hormone (GH) and prolactin (PRL) levels were investigated with the animals under urethane anesthesia. Intraventricular administration of both CCK (0.3 micrograms) and bombesin (2 micrograms) completely suppressed the GH secretion induced by FK 33-824, chlorpromazine (CPZ) or prostaglandin E2(PGE2). Both peptides also completely suppressed the PRL secretion induced by FK 33-824 or PGE2, and partially that induced by CPZ, but not that induced by domperidone. The intravenous administrations of CCK and bombesin had no or lesser potency in inhibiting the stimulated GH or PRL releases. These results indicate that the CCK and bombesin act much in the same manner to inhibit GH and PRL. These peptides may suppress the GH and PRL secretions via a hypothalamus-related action.
在乌拉坦麻醉的大鼠身上，研究了八肽胆囊收缩素（CCK）和蛙皮素对大鼠血浆生长激素（GH）和催乳素（PRL）水平的影响。脑室内注射CCK（0.3微克）和蛙皮素（2微克）均完全抑制了由FK 33 - 824、氯丙嗪（CPZ）或前列腺素E2（PGE2）诱导的GH分泌。这两种肽还完全抑制了由FK 33 - 824或PGE2诱导的PRL分泌，并部分抑制了由CPZ诱导的PRL分泌，但对多潘立酮诱导的PRL分泌无抑制作用。静脉注射CCK和蛙皮素在抑制刺激的GH或PRL释放方面无作用或作用较弱。这些结果表明，CCK和蛙皮素在抑制GH和PRL方面的作用方式非常相似。这些肽可能通过与下丘脑相关的作用来抑制GH和PRL的分泌。
