进一步的证据表明，中枢神经降压素通过刺激下丘脑释放多巴胺来抑制垂体催乳素的分泌。

Further evidence that central neurotensin inhibits pituitary prolactin secretion by stimulating dopamine release from the hypothalamus.

作者信息

Tojo K, Kato Y, Kabayama Y, Ohta H, Inoue T, Imura H

出版信息

Proc Soc Exp Biol Med. 1986 Apr;181(4):517-22. doi: 10.3181/00379727-181-42286.

Abstract

Intracerebroventricular (icv) injection of neurotensin (NT) (2 micrograms/rat) suppressed prolactin (PRL) release induced by L-5-hydroxytryptophan (1 mg/100 g body wt, iv), prostaglandin E2(1 microgram/rat, icv), and FK33-824 (10 micrograms/100 g body wt, iv), a Met5-enkephalin analog, in urethane-anesthetized or conscious rats. In contrast, NT did not suppress elevated plasma PRL levels sustained by a large dose of domperidone (10 micrograms/100 g body wt, iv), a peripheral dopamine antagonist. In in vitro experiments, NT (10(-5) M) stimulated dopamine release from perifused rat hypothalamic fragments. These results suggest that central NT inhibits PRL secretion by stimulating dopamine release from the hypothalamus into hypophysical portal blood in the rat.

摘要

在经乌拉坦麻醉或清醒的大鼠中，脑室内（icv）注射神经降压素（NT）（2微克/大鼠）可抑制由L - 5 - 羟色氨酸（1毫克/100克体重，静脉注射）、前列腺素E2（1微克/大鼠，icv）和FK33 - 824（10微克/100克体重，静脉注射，一种甲硫氨酸脑啡肽类似物）诱导的催乳素（PRL）释放。相比之下，NT并不抑制由大剂量多潘立酮（10微克/100克体重，静脉注射，一种外周多巴胺拮抗剂）维持的血浆PRL水平升高。在体外实验中，NT（10^(-5) M）刺激了经灌流的大鼠下丘脑片段释放多巴胺。这些结果表明，中枢NT通过刺激大鼠下丘脑多巴胺释放到垂体门脉血中来抑制PRL分泌。