百里胺对豚鼠回肠收缩的作用。

The effect of thymoxamine on guinea-pig ileum contractions.

作者信息

Lograno M D, Daniele E, Conte-Camerino D

出版信息

Pharmacol Res Commun. 1984 Nov;16(11):1101-10. doi: 10.1016/s0031-6989(84)80074-0.

Abstract

The effects of thymoxamine on the contractions induced in guinea-pig isolated ileum were examined. The drug was tested in a large range of concentrations (10(-8)-10(-4) M). The twitch response induced by acetylcholine was potentiated by low concentrations and inhibited by high concentrations of the alpha 1-blocking drug thymoxamine. The contractions in response to carbachol were always inhibited. Thymoxamine also affected the responses of the ileum to other stimulants: angiotensin, pentagastrin, cholecystokinin. The drug (8 X 10(-5), 5 X 10(-4) M) inhibited the calcium contraction of high K+ depolarized preparations.

摘要

研究了百里胺对豚鼠离体回肠收缩的影响。该药物在很大浓度范围内（10⁻⁸ - 10⁻⁴ M）进行了测试。低浓度的α₁阻断药百里胺可增强乙酰胆碱诱导的抽搐反应，而高浓度则抑制该反应。对卡巴胆碱的收缩反应始终受到抑制。百里胺还影响回肠对其他刺激物的反应：血管紧张素、五肽胃泌素、胆囊收缩素。该药物（8×10⁻⁵，5×10⁻⁴ M）抑制高钾去极化制剂的钙收缩。