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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Agents Actions. 1981 May;11(3):193-5. doi: 10.1007/BF01967613.

Cimetidine produced dose-dependent contractions in isolated guinea pig ileum and these responses were not blocked by mepyramine the H1-receptor antagonist. 2. Atropine competitively inhibited the cimetidine-induced contractions in the guinea pig ileum. 3. Cimetidine-induced responses were potentiated in the presence of eserine. Magnesium ions non-competitively inhibited the contractions due to cimetidine. Our findings suggest that cimetidine excites the guinea pig ileum through muscarinic receptors by releasing acetylcholine.

西咪替丁在离体豚鼠回肠中产生剂量依赖性收缩，且这些反应未被H1受体拮抗剂美吡拉敏阻断。2. 阿托品竞争性抑制豚鼠回肠中西咪替丁诱导的收缩。3. 在存在毒扁豆碱的情况下，西咪替丁诱导的反应增强。镁离子非竞争性抑制西咪替丁引起的收缩。我们的研究结果表明，西咪替丁通过释放乙酰胆碱经毒蕈碱受体兴奋豚鼠回肠。

Agents Actions. 1981 May;11(3):193-5. doi: 10.1007/BF01967613.

Cimetidine produced dose-dependent contractions in isolated guinea pig ileum and these responses were not blocked by mepyramine the H1-receptor antagonist. 2. Atropine competitively inhibited the cimetidine-induced contractions in the guinea pig ileum. 3. Cimetidine-induced responses were potentiated in the presence of eserine. Magnesium ions non-competitively inhibited the contractions due to cimetidine. Our findings suggest that cimetidine excites the guinea pig ileum through muscarinic receptors by releasing acetylcholine.

西咪替丁在离体豚鼠回肠中产生剂量依赖性收缩，且这些反应未被H1受体拮抗剂美吡拉敏阻断。2. 阿托品竞争性抑制豚鼠回肠中西咪替丁诱导的收缩。3. 在存在毒扁豆碱的情况下，西咪替丁诱导的反应增强。镁离子非竞争性抑制西咪替丁引起的收缩。我们的研究结果表明，西咪替丁通过释放乙酰胆碱经毒蕈碱受体兴奋豚鼠回肠。