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[高碳酸血症对酪氨酸和色氨酸代谢的影响]

[Effect of hypercapnia on tyrosine and tryptophan metabolism].

作者信息

Rudzit V K, Bumeĭster V K, Lerkh E E, Bol'shevich Zh A

出版信息

Biull Eksp Biol Med. 1976;81(4):416-8.

PMID:6098
Abstract

Experiments were conducted on albino rats; it was revealed that an increase in CO2 content in the inspired air (3.8%) caused disturbances in tyrosine and tryptophane metabolism. The activity of tyrosine-aminotranspherase and of tryptophane-oxygenase proved to increase in the liver; blood serum displayed a reduced concentration of free tyrosine and free total tryptophane, but the level of free tryptophane obtained by dialysis proved to rise. A possible significance of these deviations in endogenous blastomogenesis is discussed.

摘要

在白化大鼠身上进行了实验;结果显示,吸入空气中二氧化碳含量增加(3.8%)会导致酪氨酸和色氨酸代谢紊乱。肝脏中酪氨酸转氨酶和色氨酸加氧酶的活性被证明有所增加;血清中游离酪氨酸和游离总色氨酸的浓度降低,但通过透析获得的游离色氨酸水平被证明有所上升。文中讨论了这些内源性胚细胞瘤发生偏差的可能意义。

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