Kakudo K, Uematsu K, Matsuno Y, Mitsunobu M, Toyosaka A, Okamoto E, Fukuchi M
Acta Pathol Jpn. 1984 Nov;34(6):1403-10. doi: 10.1111/j.1440-1827.1984.tb00564.x.
An autopsy case of a 54-year-old woman with malignant pheochromocytoma and ectopic ACTH production was reported. Noradrenaline was increased in 24 hour urine and in the blood sample from the left adrenal vein. Hormone assay studies of the tumor tissue and plasma revealed abnormally high levels of ACTH. Formaldehyde fume induced fluorescence method demonstrated biogenic amine in the tumor cytoplasm. Electron microscopic examinations also disclosed numerous neurosecretory granules in the tumor cytoplasm. These findings confirmed that this pleomorphic carcinoma of the left adrenal gland was one of the APUDoma originating from the adrenal medulla, so-called pheochromocytoma.
报告了一例54岁患有恶性嗜铬细胞瘤并伴有异位促肾上腺皮质激素（ACTH）分泌的女性尸检病例。24小时尿中和左肾上腺静脉血样中的去甲肾上腺素升高。对肿瘤组织和血浆的激素测定研究显示ACTH水平异常升高。甲醛烟雾诱导荧光法显示肿瘤细胞质中有生物胺。电子显微镜检查也发现肿瘤细胞质中有大量神经分泌颗粒。这些发现证实，左肾上腺的这种多形性癌是起源于肾上腺髓质的一种APUD瘤，即所谓的嗜铬细胞瘤。
