Schroeder J O, Asa S L, Kovacs K, Killinger D, Hadley G L, Volpé R
J Endocrinol Invest. 1984 Apr;7(2):117-21. doi: 10.1007/BF03348400.
A 47-year old woman is presented who had a left adrenal pheochromocytoma with manifestations also indicative of ectopic ACTH syndrome. The excised adrenal gland showed both an adrenal medullary tumor and adrenal cortical hyperplasia. Immunostaining also showed the presence in the tumor of ACTH and beta endorphins. The immediate post-adrenalectomy decline of catecholamines, ACTH, cortisol and beta endorphins indicate that the adrenal itself was the source of these hormones. This patient, the thirteenth now reported in the literature, represents one form of ectopic ACTH syndrome in which the lesion is benign, and in which a successful outcome can be anticipated.
一名47岁女性患者，患有左肾上腺嗜铬细胞瘤，其表现也提示异位促肾上腺皮质激素（ACTH）综合征。切除的肾上腺显示既有肾上腺髓质肿瘤，又有肾上腺皮质增生。免疫染色还显示肿瘤中存在ACTH和β-内啡肽。肾上腺切除术后儿茶酚胺、ACTH、皮质醇和β-内啡肽立即下降，表明肾上腺本身就是这些激素的来源。该患者是文献中报道的第13例，代表了异位ACTH综合征的一种形式，其中病变是良性的，并且可以预期会有成功的结果。
