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Chromatin structure and DNA replication.

作者信息

Pülm W, Knippers R

出版信息

Adv Exp Med Biol. 1984;179:127-41. doi: 10.1007/978-1-4684-8730-5_13.

DOI:10.1007/978-1-4684-8730-5_13
PMID:6098149
Abstract

The structure of (3H) thymidine pulse labeled, replicating chromatin differs from that of non replicating chromatin by several operational criteria which are related to the higher nuclease sensitivity of replicating chromatin. We summarize the structural changes that we observe using replicating chromatin as substrate for micrococcal nuclease. The data suggest a more extended configuration of replicating compared to non replicating chromatin. We use these data to discuss a model of the chromatin structure in the vicinity of replication forks. Finally, we present data to show that the reversion of structural changes in replicative chromatin depends on continued DNA replication.

摘要

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Chromatin structure and DNA replication.
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Chromatin maturation depends on continued DNA-replication.染色质成熟依赖于持续的DNA复制。
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Structure of chromatin at deoxyribonucleic acid replication forks: location of the first nucleosomes on newly synthesized simian virus 40 deoxyribonucleic acid.脱氧核糖核酸复制叉处的染色质结构：新合成的猿猴病毒40脱氧核糖核酸上首个核小体的位置
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Replication of simian virus 40 chromatin in vitro depends on the amount of DNA polymerase alpha associated with replicating chromatin.猿猴病毒40染色质在体外的复制取决于与复制染色质相关的DNA聚合酶α的量。
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