Savage D D, Nadler J V, McNamara J O
Brain Res. 1984 Dec 3;323(1):128-31. doi: 10.1016/0006-8993(84)90274-9.
The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less than in electrode-implanted unstimulated controls. Specific binding in the inner third of the dentate molecular layer was reduced to a lesser degree. These observations demonstrate that kainic acid receptors are down-regulated by kindling stimulation.
通过放射自显影法检测了[3H] kainic酸与经杏仁核或角束强直刺激点燃的大鼠海马膜的特异性结合。在第4 - 5级点燃性癫痫发作3次中的最后一次发作后一天，CA3区透明层中[3H] kainic酸的特异性结合比植入电极但未受刺激的对照组减少了47 - 61%。齿状分子层内三分之一处的特异性结合减少程度较小。这些观察结果表明，点燃刺激可使kainic酸受体下调。
