Triggle D J
J Asthma. 1984;21(6):375-85. doi: 10.3109/02770908409083220.
The role of Ca2+ as a mediator of many cellular responses, including stimulus-secretion and excitation-contraction coupling, is reviewed. Pathways of Ca2+ mobilization are discussed in terms of both intracellular and plasmalemmal processes. The extent to which specific antagonists exist, active at these several sites, is noted, with particular emphasis on the clinically available Ca2+ channel antagonists, including verapamil, nifedipine, and diltiazem.
本文综述了钙离子（Ca2+）作为许多细胞反应介质的作用，包括刺激-分泌偶联和兴奋-收缩偶联。从细胞内和质膜过程两方面讨论了Ca2+动员的途径。文中指出了在这些不同位点具有活性的特异性拮抗剂的存在程度，特别强调了临床上可用的Ca2+通道拮抗剂，包括维拉帕米、硝苯地平和地尔硫䓬。
