Colin J, Chastel C, Volant A
J Fr Ophtalmol. 1984;7(10):603-7.
The combination therapy of corticosteroids and antiviral agent is often necessary in the treatment of different forms of ocular herpes. The association of superficial ulceration with severe stromal inflammation indicates the possible use of ths therapy. An experimental study was performed in rabbits to evaluate if Trifluorothymidine (TFT) used in combination with topical corticosteroids can heal herpetic superficial ulcerations. Biomicroscopic and histopathologic lesions were compared with those of herpetic control eyes, TFT treated eyes and corticosteroid treated eyes. TFT plus corticosteroid treated lesions showed a clinically favourable evolution comparable to that of TFT treated rabbits without corticosteroid. However anatomopathologic examination revealed stromal alterations with herpetic capsids in keratocytes.
在治疗不同形式的眼部疱疹时，皮质类固醇和抗病毒药物的联合治疗通常是必要的。浅表溃疡与严重基质炎症的关联表明可能需要使用这种治疗方法。在兔子身上进行了一项实验研究，以评估三氟胸苷（TFT）与局部皮质类固醇联合使用是否能治愈疱疹性浅表溃疡。将生物显微镜和组织病理学病变与疱疹对照眼、TFT治疗眼和皮质类固醇治疗眼的病变进行了比较。TFT加皮质类固醇治疗的病变在临床上显示出与未使用皮质类固醇的TFT治疗兔子相当的良好进展。然而，解剖病理学检查发现角膜细胞中有疱疹衣壳的基质改变。
