Lemaire V, Gueris J, Cassou M, Ryckewaert A
Rev Rhum Mal Osteoartic. 1977 Dec;44(12):709-13.
The plasma parathormone was measured by radioimmunological determination in 23 cases of cancer with bone metastases, 8 of mammary origin. In 11 cases the plasma parathormone (iPTH) was less than 4 ng/ml (lower normal limit), as might be expected in view of the hypercalcemia. In 12 cases the iPTH was higher than 4 ng/ml, in 8 of these higher than 8 ng/ml (upper normal limit). These results are suggestive of the role of a substance analogous to parathormone in the genesis of the hypercalcaemia and peritumoral bone resorption of bone metastases of solid tumors.
采用放射免疫法对23例伴有骨转移的癌症患者进行血浆甲状旁腺激素检测，其中8例为乳腺癌骨转移。鉴于存在高钙血症，11例患者的血浆甲状旁腺激素（iPTH）低于4 ng/ml（正常下限）。12例患者的iPTH高于4 ng/ml，其中8例高于8 ng/ml（正常上限）。这些结果提示，在实体瘤骨转移的高钙血症及肿瘤周围骨吸收的发生过程中，一种类似于甲状旁腺激素的物质发挥了作用。
