Hubault A, Tubiana M
Rev Rhum Mal Osteoartic. 1977 Dec;44(12):733-40.
The physiopathological mechanisms leading to precipitation of pyrophosphate in the articular cartilage remain unclear. Numerous findings suggest an error in pyrophosphate metabolism: excessive production or defective degradation, a primary modification of the fundamental substance leading to crystallization, a chondrocyte dysfunction being a possible cause of these two anomalies. The relationships between deposition of calcium pyrophosphate and changes in the subchondral osseous plaque common to several metabolic diseases are even more mysterious.
导致焦磷酸盐在关节软骨中沉积的生理病理机制仍不清楚。众多研究结果表明焦磷酸盐代谢存在异常：产生过多或降解缺陷，基质的原发性改变导致结晶，软骨细胞功能障碍可能是这两种异常的原因。焦磷酸钙沉积与几种代谢性疾病共有的软骨下骨板变化之间的关系更为神秘。
