Sárközi A M, Németh-Csóka M
Z Rheumatol. 1984 Jan-Feb;43(1):30-5.
The influence of Arteparon on crystal formation in vitro has been examined in calcium orthophosphate and in calcium pyrophosphate mixtures. Similar factors may be operative in the cartilage calcification processes, and thus in chondrocalcinosis. Authors have ascertained that Arteparon - like chondroitin sulphate - inhibits crystal separation. The optimal concentration for this inhibition lies in the range of the proteoglycan content of normal cartilage. Where there are physiological phosphate-pyrophosphate ratios and a low magnesium concentration, it is certain that Arteparon has an inhibiting effect. Apart from the spatial structure of the substance, the importance of negative charge density for the inhibition of separation of calcium phosphate and pyrophosphate crystals is thought to contribute to this effect of Arteparon.
已在磷酸钙和焦磷酸钙混合物中研究了阿特帕龙对体外晶体形成的影响。类似的因素可能在软骨钙化过程中起作用，进而在软骨钙质沉着症中起作用。作者已确定，阿特帕龙——类似于硫酸软骨素——可抑制晶体分离。这种抑制作用的最佳浓度处于正常软骨蛋白聚糖含量范围内。在存在生理磷酸-焦磷酸比率且镁浓度较低的情况下，阿特帕龙肯定具有抑制作用。除了该物质的空间结构外，负电荷密度对抑制磷酸钙和焦磷酸钙晶体分离的重要性被认为促成了阿特帕龙的这种作用。
