[洋地黄苷的作用机制]
[Mechanism of action of digitalis glycosides].
作者信息
Swynghedauw B
出版信息
Ann Cardiol Angeiol (Paris). 1984 Dec;33(8):563-5.
PMID:6099080
Abstract
It appears well established that the inotropic effect of digitalis is due initially to inhibition of the sodium pump (Na-K-ATPase), initiating a cascade effect which in turn increases "diastolic" intracellular Ca2+, which then increases "systolic" intracellular Ca2+ responsible for the inotropic effect.
摘要
洋地黄的正性肌力作用最初似乎是由于抑制钠泵（Na-K-ATP酶），引发级联效应，进而增加“舒张期”细胞内钙离子浓度，继而增加产生正性肌力作用的“收缩期”细胞内钙离子浓度，这一点似乎已得到充分证实。
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