Murphy M B, Brown M J, Dollery C T
Br J Clin Pharmacol. 1984 Dec;18(6):955-8. doi: 10.1111/j.1365-2125.1984.tb02570.x.
To determine whether vascular postsynaptic alpha 2-adrenoceptors are innervated by sympathetic nerves in man, normal volunteers were infused for 90 min with angiotensin II (A II) and the alpha 2-adrenoceptor agonist alpha-methylnoradrenaline (MNA) in a double-blind cross-over study. Whilst systolic blood pressure returned to baseline within 5 min of terminating the A II infusion it remained elevated 40 min after stopping MNA. The prolongation of the pressor response to MNA, a substrate for neuronal uptake, was probably due to activation of alpha 2-adrenoceptors by MNA re-released from contiguous sympathetic nerve endings. The proximity of alpha 2-adrenoceptors to sympathetic nerve terminals suggests that they could contribute to blood pressure regulation in man.
为了确定人体血管突触后α₂肾上腺素能受体是否受交感神经支配，在一项双盲交叉研究中，对正常志愿者输注血管紧张素II（A II）和α₂肾上腺素能受体激动剂α-甲基去甲肾上腺素（MNA）90分钟。在终止A II输注后5分钟内收缩压恢复到基线水平，而在停止MNA输注后40分钟收缩压仍处于升高状态。对作为神经元摄取底物的MNA的升压反应延长，可能是由于从相邻交感神经末梢重新释放的MNA激活了α₂肾上腺素能受体。α₂肾上腺素能受体与交感神经末梢接近，表明它们可能参与人体血压调节。
