Brown M J, Dollery C T
Clin Exp Hypertens A. 1984;6(1-2):539-49. doi: 10.3109/10641968409062582.
In man, circulating adrenaline has little or no direct effect on the control of blood pressure. A small proportion of adrenaline secreted by the adrenal medulla is accumulated in sympathetic nerve endings and may be re-released by sympathetic nerve stimulation. Recent pharmacological studies have suggested that adrenaline acts on a presynaptic beta-receptor on sympathetic nerve endings to facilitate noradrenaline release, and it has been proposed that adrenaline re-released from these nerve endings is therefore a functionally important "co-transmitter". Intermittently elevated secretion of adrenaline from the adrenal medulla could therefore lead indirectly to a sustained increase in neuronal release of noradrenaline and hence to hypertension.
在人类中，循环中的肾上腺素对血压控制几乎没有直接影响。肾上腺髓质分泌的一小部分肾上腺素会积聚在交感神经末梢，可能会通过交感神经刺激再次释放。最近的药理学研究表明，肾上腺素作用于交感神经末梢的突触前β受体以促进去甲肾上腺素释放，因此有人提出从这些神经末梢再次释放的肾上腺素是一种功能上重要的“共同递质”。因此，肾上腺髓质间歇性分泌增加可能间接导致去甲肾上腺素的神经元释放持续增加，从而导致高血压。
