St-Arnaud R, Chabot J G, Pelletier G, Labrie F, Walker P
Biochimie. 1984 Jul-Aug;66(7-8):515-30. doi: 10.1016/0300-9084(84)90146-9.
Epidermal growth factor (EGF) is a Mr 6045 polypeptide first characterized for its ability to stimulate mitogenesis in epidermal and epithelial cells. The first step in the action of the growth factor is its binding to specific, high affinity membrane receptors. These receptors have been studied in a number of tissues and cell culture lines. The level of EGF receptors is modulated by many agents. EGF down-regulates its receptor. In addition, the number of EGF receptors is decreased by other growth factors (platelet-derived growth factor; transforming growth factor), by many tumor promoters and by viral transformation. Several hormones also can regulate EGF binding in its target tissues.
表皮生长因子（EGF）是一种分子量为6045的多肽，最初因其能够刺激表皮和上皮细胞的有丝分裂而被鉴定。生长因子作用的第一步是它与特定的高亲和力膜受体结合。这些受体已在许多组织和细胞系中得到研究。表皮生长因子受体的水平受到多种因素的调节。表皮生长因子会下调其受体。此外，其他生长因子（血小板衍生生长因子；转化生长因子）、许多肿瘤启动子和病毒转化都会使表皮生长因子受体的数量减少。几种激素也可以调节表皮生长因子在其靶组织中的结合。
